Wilms tumor and breast cancer

Reply to Wilms tumor and breast cancer.

Malignant tumors are a well-documented late complication of therapy for Wilms tumor. Lange et al reported that female survivors of Wilms tumor who were treated with radiotherapy to the thorax at a dose of 12 to 14 gray (Gy) had an elevated risk of developing early breast cancer, with nearly 15% having invasive disease by age 40 years. Radiotherapy to the thorax is a risk factor for male breast ...

MiR-21 Expression in Wilms’ Tumor

Background and Objective: Wilms’ tumor (WT) is the most common genitourinary tract tumor in children. MicroRNAs (miRNAs) are small non-coding RNAs; their role in the pathogenesis of many types of human cancers has been identified. We aimed to evaluate the expression of miR-21, a well-known oncomir, in WT tissue samples which is a very common urinary tract malignancy in children...

Wilms Tumor

[Wilms' tumor].

Today the prognosis in children with nephroblastoma is excellent. With the combination of surgery, chemotherapy and radiation more than 80% of children can be cured. Because of acute toxicity and late effects of treatment (scoliosis, cardiotoxicity, fertility problems and second malignancies) a major issue in the management of children with this kind of malignancy is the reduction of chemothera...

High expression of Wilms' tumor suppressor gene predicts poor prognosis in breast cancer patients.

PURPOSE The prognostic significance of the Wilms' tumor suppressor gene(WT1) mRNA expression was evaluated in patients with invasive breast cancer. EXPERIMENTAL DESIGN WT1 mRNA expression in tumor tissues (n = 99) was examined by a quantitative, real-time PCR assay. RESULTS No significant association was observed between WT1 mRNA levels and clinicopathological parameters such as menopausal ...